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研究盐酸阿霉素缓释剂在大鼠和犬体内的药物动力学。方法 :用高效液相色谱法测定血浆阿霉素的浓度。结果 :大鼠皮下植入盐酸阿霉素缓释剂后 ,血浆阿霉素可持续、缓慢释放 ;犬皮下植入 2mg·kg-1盐酸阿霉素缓释剂后 ,其有效血浆浓度曲线呈一室模型特点 ,但其维持有效血浆浓度 (0 .0 4μg .ml-1)时间长达 16 8h ,其峰值浓度仅为iv同剂量血浆阿霉素的4.6 %。结论 :盐酸阿霉素缓释剂有显著的缓释作用。
To study the pharmacokinetics of sustained release doxorubicin hydrochloride in rats and dogs. Methods: The concentration of doxorubicin in plasma was determined by high performance liquid chromatography. Results: Adriamycin hydrochloride sustained-release tablets were implanted subcutaneously in rats, and the sustained and slow release of doxorubicin was achieved. The effective plasma concentration of 2 mg · kg-1 doxorubicin hydrochloride was implanted subcutaneously in dogs However, its peak plasma concentration (0.040 μg. Ml-1) was as long as 168 h, with a peak concentration of only 4.6% of the same dose of plasma doxorubicin. Conclusion: Adriamycin hydrochloride sustained-release agent has a significant sustained release effect.