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目的总结早期应用局部亚低温治疗大面积脑梗死的经验及临床意义。方法选择发病在6～24h的大面积脑梗死患者45例,随机分为亚低温治疗组23例,常规治疗组即对照组22例。两组患者均在入院时、第7d、第14d、第30d进行SSS神经功能缺失评分。结果两组SSS神经功能评分第14d、第30d治疗组有明显低于对照组(P<0.05)。治疗组总有效率(95.7%),明显高于对照组(68.2%)(P<0.05)。结论局部亚低温治疗可明显改善重症脑梗死的神经功能及预后,起到脑保护作用,且远期疗效更具有临床价值,无不良反应。
Objective To summarize the experience and clinical significance of early application of local mild hypothermia in treating large area cerebral infarction. Methods Forty-five patients with large-area cerebral infarction who developed from 6 to 24 hours were randomly divided into mild hypothermia treatment group (n = 23) and control group (n = 22). Patients in both groups were admitted to hospital, the first 7d, 14d, 30d SSS neurological deficit score. Results The SSS scores of the two groups were significantly lower than those of the control group on the 14th and 30th days (P <0.05). The total effective rate (95.7%) in the treatment group was significantly higher than that in the control group (68.2%) (P <0.05). Conclusion Local mild hypothermia treatment can significantly improve the neurological function and prognosis of severe cerebral infarction, play a role in cerebral protection, and more long-term efficacy of clinical value, no adverse reactions.