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【目的】 为了探讨氟哌啶醇不同服法治疗多发性抽动症 (TS)的疗效及副作用。 【方法】 16 2例TS患儿随机分两组 :治疗组 87例 ,氟哌啶醇 0 .0 2 5～ 0 .0 5mg/kg .次 ,每天睡前顿服 ;对照组 75例 ,药物及每次量同前 ,每日三次 ,三个月一疗程。 【结果】 第一疗程治疗组显效 46例 ,进步 2 7例 ,有效率 83 .9% ;对照组显效 41例 ,进步2 3例 ,有效率 85 .3 % (P >0 .0 5 )。第二疗程有效率分别为 97.7%及 88.0 % (P <0 .0 5 )。两组症状治疗前及第一疗程后评分结果P均 >0 .0 5 ;第二疗程后评分分别为 (0 .6 78± 0 .70 5 )、(0 .9± 0 .83) ,P <0 .0 5。而副作用评分 :对照组12 4分 ,治疗组 9分 (t=19.91,P <0 .0 1)。 【结论】 说明治疗组疗效比对照组高 ,而副作用明显低于治疗组 ,差异非常显著。
【Objective】 To investigate the curative effect and side effects of haloperidol different treatment on multiple twitch syndrome (TS). 【Methods】 One hundred and sixty-two children with TS were randomly divided into two groups: treatment group 87 cases, haloperidol 0 .025 ~ 0. 05 mg / kg. And each volume with the former, three times a day, three months a course of treatment. 【Results】 The first course of treatment group was significantly improved 46 cases, progress in 27 cases, the effective rate was 83.9%; the control group markedly effective in 41 cases, progress in 23 cases, the effective rate was 85.3% (P> 0.05). The second course of treatment efficiency were 97.7% and 88.0% (P <0.05). The scores of both groups before and after the first course of treatment were all higher than 0.05 (P <0.05). The scores after the second course of treatment were (0 .6 78 ± 0 .70 5), (0 .9 ± 0 .83), P <0 .0 5. The side effects score was 12 4 in the control group and 9 in the treatment group (t = 19.91, P <0.01). 【Conclusion】 The treatment group showed higher efficacy than the control group, while the side effects were significantly lower than the treatment group, the difference was significant.