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从19世纪末期科学家们就开始观察染色体的末端,并相继提出了端粒与端粒酶的概念,经历了一个多世纪的探索,直到2009年诺贝尔生理学或医学奖揭晓,人们对端粒与端粒酶的结构及作用有了更深层次的认识。研究发现,端粒、端粒酶与机体衰老、癌变具有密切的关系。端粒、端粒酶已成为生命科学领域的研究焦点之一。人们试图通过研究它们的结构和功能,以及它们与机体的关系来了解更多生命的奥秘。在此就端粒、端粒酶的发现历程以及它们在机体衰老、癌变方面的研究进行综述。
From the late 19th century scientists began to observe the chromosome ends, and have come up with the concept of telomere and telomerase, has gone through more than a century of exploration until the Nobel Prize in Physiology or Medicine in 2009 was announced, the people of telomere and The structure and function of telomerase have a deeper understanding. The study found that telomere, telomerase and aging, cancer is closely related. Telomeres and telomerase have become the focus of research in the life sciences. People try to understand more about the mysteries of life by studying their structure and function, and their relationship to the body. In this paper, telomere, telomerase discovery process and their research in the body aging, canceration are reviewed.