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目的:评估心肌梗死患者血清IL-17水平在心肌梗死后心衰及心律失常中的筛选价值。方法:心肌梗死患者入院确诊后通过酶联免疫吸附法(ELISA)对其进行血清IL-17水平检测,对患者进行随访,记录患者心肌梗死后心衰和心率失常的发生情况,比较149例患者梗死后发生心衰(n=48)和心律失常患者(n=49)和仅有心肌梗死患者(n=52)血清IL-17水平的变化;绘制受试者工作特征曲线(ROC)分析IL-17对心肌梗死后心衰和心律失常的筛选价值。结果:心肌梗死后发生心衰者血清IL-17水平[(36.41±10.96)pg·ml~(-1)]和心肌梗死后心律失常者血清IL-17水平[(24.10±8.07)pg·ml~(-1)]显著高于仅有心肌梗死患者[(16.70±7.92)pg·ml~(-1)](P<0.001)。血清IL-17在筛选心肌梗死后心衰和心律失常中的曲线下面积(AUC)分别为0.91和0.771。结论:心肌梗死后出现心衰和心律失常患者血清IL-17水平显著升高;IL-17水平在心肌梗死后心衰发生中具有一定筛选价值,而在心肌梗死后心律失常的筛选中并不理想。
Objective: To evaluate the screening value of serum IL-17 in patients with myocardial infarction after myocardial infarction heart failure and arrhythmia. Methods: Serum IL-17 levels were detected by enzyme-linked immunosorbent assay (ELISA) in patients with myocardial infarction. The patients were followed up and recorded the incidence of heart failure and arrhythmia after myocardial infarction. A total of 149 patients Serum levels of IL-17 in patients with heart failure (n = 48) and arrhythmia (n = 49) and those with myocardial infarction alone (n = 52) after infarction were plotted; receiver operating characteristic curves (ROC) -17 on myocardial infarction heart failure and arrhythmia screening value. Results: Serum levels of IL-17 in CHF patients [(36.41 ± 10.96) pg · ml -1] and IL-17 levels in arrhythmia patients after myocardial infarction [(24.10 ± 8.07) pg · ml ~ (-1)] in patients with myocardial infarction [(16.70 ± 7.92) pg · ml -1] (P <0.001). The area under the curve (AUC) for serum IL-17 in screening for heart failure and arrhythmia after myocardial infarction was 0.91 and 0.771, respectively. CONCLUSIONS: Serum IL-17 levels are significantly elevated in patients with heart failure and arrhythmia after myocardial infarction. The level of IL-17 has a certain screening value in the occurrence of heart failure after myocardial infarction, but not in the screening of arrhythmia after myocardial infarction ideal.