1975年K?hler等首先成功地应用细胞融合技术生产单克隆抗体,这在临床免疫学中揭开了新的一页,它不仅为制备抗血清制剂开创了一条新途径,而且也大大提高了对许多疾病的诊断及治疗水平.近年来单克隆抗体在组织器官移植中的应用日渐增多,现概述如下.用于组织抗原配型进行器官移植时,供体与受体之间人白细胞抗原(HLA)的相容程度与移植的成败有密切关系,HLA相容的亲属之间的肾移植,1、2年的存活率分别为90%和85%,HLA- In 1975 K? Hler and other first successful application of cell fusion technology to produce monoclonal antibodies, which opened a new chapter in clinical immunology, which not only for the preparation of antiserum preparations to create a new way, but also greatly improved For many diseases diagnosis and treatment level.In recent years, the application of monoclonal antibodies in tissue and organ transplantation is increasing, are summarized as follows.For tissue antigen matching for organ transplantation, donor and recipient of human leukocyte antigen ( HLA) compatibility is closely related to the success or failure of transplantation. The renal transplant between HLA-compatible relatives has a survival rate of 90% and 85% for 1 and 2 years respectively. HLA-