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腺苷对缺血再灌注心肌具有保护作用,其主要机制为:改善心肌微循环、抑制中性粒细胞功能、抑制氧自由基产生、改善心肌能量代谢、维持钙稳态、促进血管修复及改善心室重构、介导预处理与后处理效应,这些作用主要是由分布于心肌的各型腺苷受体介导的,目前已被用于心肌梗死、心律失常的防治及心脏停搏法、经皮冠状动脉内成型术、心脏移植术中。
Adenosine has a protective effect on myocardial ischemia-reperfusion injury, its main mechanism is to improve myocardial microcirculation, inhibit neutrophil function, inhibit the production of oxygen free radicals, improve myocardial energy metabolism, maintain calcium homeostasis and promote vascular repair and improvement Ventricular remodeling, preconditioning and postconditioning mediation, these effects are mainly mediated by various types of adenosine receptors located in the myocardium, and have been used in the prevention and treatment of myocardial infarction, arrhythmia and cardiac arrest, Percutaneous transluminal coronary angioplasty and heart transplantation.