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本文测定了97例正常及不育男性精子及精浆中的乳酸脱氢酶C_4同功酶(LDH-C_4)活性。精浆/精子中该同功酶活性的比值在正常对照、精液常规正常而不育(不育Ⅰ组)、精液常规不正常的不育(不育Ⅱ组)和少精症组中依次为0.528,0.880,2.85和4.01(中位数值)。各不育组与对照组间均差异显著(P<0.005及P<0.0005)。以mU/10~6精子表示时,不育Ⅰ和Ⅱ组精浆中的LDH-C_4活性大于正常男性;精子中的活性则小于正常男性(P<0.005及P<0.0005)。此外,精子中LDH总活性与LDH-C_4活性之间有良好的正相关(r=0.9593)。
In this study, 97 lactate dehydrogenase (C_4) isoenzymes (LDH-C_4) in normal and infertile men were measured. In the seminal plasma / spermatozoa, the ratio of the isoenzyme activity was significantly higher in the normal control group, normal normal semen sepsis (infertility group I), abnormal semen normal infertility (infertility group II) and oligospermia group 0.528, 0.880, 2.85 and 4.01 (median values). There was significant difference between each sterile group and control group (P <0.005 and P <0.0005). When expressed in mU / 10 ~ 6 spermatozoa, LDH-C_4 activity in seminal plasma of infertile I and II groups was greater than that of normal males; sperm motility was less than that of normal males (P <0.005 and P <0.0005). In addition, there was a good positive correlation between total LDH activity and LDH-C_4 activity in sperm (r = 0.9593).