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目的探讨超高倍显微镜检测慢性咽炎患者咽部分泌物中幽门螺杆菌(HP)的分布情况。方法对慢性咽炎患者295例和正常对照30例,采用咽拭子均匀涂片,超高倍显微镜下观察,放大20 000倍,根据观察需要选择暗视野相差视野进行活体观察,由一名专业人员进行结果判定。卡方检验评价两组HP阳性率的差异。结果慢性咽炎患者中229例咽部分泌物中检测到幽门螺旋杆菌(77.63%,229/295),66例未发现HP(22.37%,66/295);正常对照组中,30例咽部分泌物中2例检测到幽门螺旋杆菌(6.67%,2/30),其余28例(93.33%,28/30)幽门螺旋杆菌阴性,经卡方检验χ2=6.670,P<0.05。结论幽门螺旋菌可能是慢性咽炎患者咽部一种被忽视的致病菌,超高倍显微镜有可能成为筛查咽部分泌物中幽门螺旋菌的一种新方法,幽门螺旋菌感染与喉咽反流的关系还需要进行进一步研究证实。
Objective To investigate the distribution of Helicobacter pylori (HP) in pharyngeal secretions of patients with chronic pharyngitis by ultra-high power microscope. Methods 295 cases of chronic pharyngitis patients and 30 cases of normal control, using throat swab uniform smear under ultra-high magnification microscope, magnification 20,000 times, according to the observation need to select the dark field of vision difference in vivo observation, by a professional staff The result is judged. Chi-square test to evaluate the difference between the two groups of HP positive rate. Results Helicobacter pylori (77.63%, 229/295) were detected in 229 pharyngeal secretions of patients with chronic pharyngitis and 66 (29.35%) were not found in 66 cases. In the control group, 30 cases of pharyngeal secretions Helicobacter pylori (6.67%, 2/30) was detected in 2 cases and Helicobacter pylori was negative in the remaining 28 cases (93.33%, 28/30). The chi square test was used as χ2 = 6.670, P <0.05. Conclusion Helicobacter pylori may be a neglected pharyngeal pathogen in patients with chronic pharyngitis. It is possible that ultra-high magnification microscopy may be a new method for screening H. pylori in pharyngeal secretions. Helicobacter pylori infection and hypopharyngeal Flow relationship also needs further study confirmed.