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细胞凋亡是机体维持自稳态和免疫系统正常发育的重要机制，也是肾脏发生、发育及肾脏疾病的病理损伤与修复过程中必不可少的环节，Ｆａｓ系统不仅参与肾小球损伤过程中肾细胞的凋亡，也参与急性肾移植的排斥。此外，系统性红斑狼疮及狼疮性肾炎的发展与Ｆａｓ功能缺陷相关
Apoptosis is an important mechanism for the body to maintain the homeostasis and the normal development of the immune system. It is also an indispensable link in the process of pathological injury and repair of the kidney, development and kidney disease. Fas system not only participates in the process of glomerular injury Cell apoptosis is also involved in acute kidney transplant rejection. In addition, the development of systemic lupus erythematosus and lupus nephritis is associated with Fas dysfunction