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目的 设计开放式创伤动物模型并进行相关实验研究,探讨壳聚糖/左氧氟沙星长效缓释敷料168 h内治愈开放式创伤的可行性.方法 用手术刀致30只成年日本大耳白背部形成开放式创伤,伤口处加1 mL c=1×108 cfu/mL的金黄色葡萄球菌ATCC 6538,大肠杆菌8099和绿脓杆菌CMCC(B) 10010的混合菌液后包扎,按不同包扎材料分为材料组,对照组和空白组,分别在6 h、24h、72 h、120 h、进行临床观察,同时取活体组织通过动态浊度法检测细菌内毒素,分析伤口感染防治的效果.结果 壳聚糖/左氧氟沙星长效缓释敷料在促进伤口愈合和抗感染的效果显著优于对照组和空白组.结论 壳聚糖/左氧氟沙星长效缓释敷料能在168 h内有效控制创面细菌感染,并具有促进创面愈合作用,对于伤员大规模爆发、开放性软组织损伤无法及时清创时,能够起到良好创面包扎保护、抗感染的作用.“,”Objective The effect of chitosan/levofloxac wound dressing on severe open wound was studied in the rabbit model in 168 h. Methods Thirty Japanese white rabbits with severe open wounds were randomly divided into three groups according to the different wound dressing. The test group were treated with CS/LVFX wound dressing, the control group were treated with nanometer silver dressing and blank group with gauze. Wound was added 1 mL 1×108 cfu/mL mixed solution with Staphylococcus aureus ATCC 6 538,Escherichia coli 8 099 and P.aeruginosa CMCC (B) 10010 in each group before bound up. The content of Endotoxin in wound and healing time were measured to analyze the anti-infection of three wound dressings. Results CS/LVFX wound dressing was the best one in anti-infection. Conclusion CS/LVFX wound dressing is a better choice in severe open wound treatment when a massive wound break out.