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[目的]比较序贯疗法和传统三联疗法治疗幽门螺杆菌阳性溃疡的临床疗效。[方法]86例Hp阳性的消化性溃疡的患者随机分为两组,序贯组和三联组,每组43例,比较两组的Hp根除、治疗后溃疡愈合及症状缓解情况。[结果]序贯组Hp清除率为90.7%明显高于三联组Hp清除率74.4%(P﹤0.05)。序贯组的愈合率为90.7%明显高于三联组的72.1%(P﹤0.05)。而两组腹痛、反酸、嗳气和腹胀积分比较差异无统计学意义(P﹥0.05)。[结论]序贯疗法与传统的三联疗法比较,能够更有效的根除Hp感染,促进溃疡的愈合,有望替代三联疗法成为治疗幽门螺杆菌阳性溃疡的临床一线用药。
[Objective] To compare the clinical efficacy of sequential therapy and traditional triple therapy in the treatment of Helicobacter pylori positive ulcer. [Method] 86 patients with Hp-positive peptic ulcer were randomly divided into two groups, sequential group and triple group, with 43 patients in each group. Hp eradication, healing and symptom relief of ulcer were compared between the two groups. [Result] The Hp clearance rate of sequential group was 90.7%, significantly higher than that of triple combination group (74.4%, P <0.05). The healing rate of sequential group was 90.7%, which was significantly higher than that of triple group (72.1%, P <0.05). The two groups of abdominal pain, acid reflux, belching and abdominal distension score was no significant difference (P> 0.05). [Conclusion] Compared with traditional triple therapy, sequential therapy is more effective in eradicating Hp infection and promoting the healing of ulcer. It is expected that triple therapy will become a first-line treatment for Helicobacter pylori positive ulcer.