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目的研究重型再生障碍性贫血 (SAA)的治疗方案。方法治疗组 2 1例SAA患者中 19例给予环孢霉素A(CsA)联合基础治疗 (SSL方案 )及造血生长因子 (HGF)治疗 ,2例给予抗胸腺细胞球蛋白 (ATG)联合SSL方案及HGF治疗 ,其中 1例为CsA方案治疗无效后改用ATG方案治疗。对照组 16例单用SSL方案治疗。结果治疗组 2 1例患者中 14例有效 ,有效率 6 6 .6 % ,其中 4例己达治愈标准。随访 3年余血象及骨髓象均正常。对照组 16例患者治疗后无一例达到有效标准。治疗组与对照组相比 ,不但疗效明显提高 ,而且早期感染率及病死率均降低。结论免疫抑制剂联合SSL方案及HGF治疗SAA较单用SSL方案疗效明显提高 ,可降低早期感染率及病死率。
Objective To study the treatment of severe aplastic anemia (SAA). Methods Nineteen 21 patients with SAA were treated with cyclosporine A (CsA) combined with basic therapy (SSL) and hematopoietic growth factor (HGF). Two patients were given anti-thymocyte globulin (ATG) combined with SSL And HGF treatment, of which 1 case of CsA regimen was treated with ATG instead of treatment. Control group, 16 cases of single SSL treatment. Results In the treatment group, 14 of the 21 patients were effective and the effective rate was 66.6%. Four of them had cured the standard. Follow-up more than 3 years of blood and bone marrow as normal. None of the 16 patients in the control group achieved effective standards after treatment. The treatment group compared with the control group, not only significantly improved efficacy, and early infection and mortality were reduced. Conclusion The combination of immunosuppressive agents and SSL and HGF significantly improved the efficacy of SAA compared with the single SSL protocol, which can reduce the early infection rate and mortality.