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用酶联免疫吸咐试验检测神经精神性狼疮（ＮＰＬＥ）、非ＮＰＬＥ狼疮患者、ＳＬＥ脑血管疾病患者及正常对照者血清及脑脊液中抗心磷脂抗体（ＡＣＬ抗体）。结果提示ＮＰＬＥ组ＡＣＬ抗体阳性率在血清中为９０．０％、脑脊液为３３．０％，非ＮＰＬＥ狼疮组ＡＣＬ阳性率在血清中为４４．０％、脑脊液为８．３％，非ＳＬＥ脑血管疾病组ＡＣＬ阳性率在血清中为５０．０％、脑脊液为４０．０％，正常人组ＡＣＬ阳性率在血清及脑脊液中均为０．０％。ＡＣＬ抗体在ＮＰＬＥ组与其它组之间（除非ＳＬＥ脑血管疾病组脑脊液中ＡＣＬ抗体）有显著差别，它的检测将有助于ＮＰＬＥ的临床诊断
Serum and cerebrospinal fluid anticardiolipin antibodies (ACL antibodies) were detected by enzyme-linked immunosorbent assay in patients with neuroleptic lupus nephritis (NPLE), non-NPLE lupus, patients with SLE cerebrovascular disease and normal controls. The results showed that the positive rate of ACL antibody in NPLE group was 90.0% in serum and 33.0% in cerebrospinal fluid. The positive rate of ACL in non-NPLE lupus group was 44.0% in serum and 8.3% in cerebrospinal fluid. The non-SLE brain The positive rate of ACL in vascular disease group was 50.0% in serum and 40.0% in cerebrospinal fluid. The positive rate of ACL in normal people was 0.0% in both serum and cerebrospinal fluid. ACL antibody was significantly different between the NPLE group and the other groups (except for ACL antibodies in cerebrospinal fluid of patients with SLE cerebrovascular disease) and its detection would be helpful for the clinical diagnosis of NPLE