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1摘要高盐饮食引起肾髓质环氧合酶(COX)2表达,与此同时肾髓质内灌注选择性的COX2抑制剂的高盐饮食大鼠出现血压升高。本研究探讨前列腺素引起的COX2的抗高血压效果。经免疫印迹和实时PCR检测,高盐饮食下C57BL/6J小鼠肾髓质中的COX2和微粒体中的前列
1 Abstract High-salt diet induces the expression of cyclooxygenase (COX) 2 in the medulla, while elevated blood pressure appears in the high-salt diet rats injected with selective COX2 inhibitors in the medulla. This study explored the anti-hypertensive effects of prostaglandins on COX2. Western blotting and real-time PCR detection of COX2 and microsomes in the renal medulla of C57BL / 6J mice under high salt diet