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在细胞免疫学方面,曾有人用动物试验或临床观察证实,用铍作抗原,与试验性铍病动物或慢性铍病患者的血液白细胞同时进行培养,可产生单核细胞移动抑制因子(MIF),从而说明慢性铍病具有迟发型变态反应的性质。我们也曾经用白细胞移动抑制试验(MIT)方法,对32名铍作业工人进行了免疫学观察,发现有肺部改变者MIT阳性率较高,而正常人均为阴性。因此MIT检查可能做为早期铍病诊断以及与其他疾患鉴别诊断的参考指标。
In cellular immunology, there have been animal experiments or clinical observations confirmed that the use of beryllium as an antigen, and experimental beryllium animals or patients with chronic beryllium leukocytes in culture can produce monocyte migration inhibitory factor (MIF) , Indicating the nature of chronic beryllium with delayed-type hypersensitivity. We also used the leukocyte migration inhibitory assay (MIT) method to immunologically observe 32 beryllium workers and found that the positive rate of MIT was higher in patients with lung changes than in normal controls. Therefore, MIT examination may be used as early diagnosis of beryllium disease and other diseases, the differential diagnosis of reference indicators.