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目的:研究北京地区妇产科门诊患者人类乳头瘤状病毒(HPV)感染现状及与年龄的相关性,为HPV疫苗的临床应用提供流行病学资料。方法:采集2013年4月至2014年5月于首都医科大学宣武医院妇产科门诊就诊患者的宫颈细胞标本1 999例,利用凯普电导流核酸分子杂交技术对HPV-DNA进行基因分型,对不同年龄段的HPV感染率进行年龄分层分析,结合年龄信息进行统计分析。结果:在1 999例标本中,HPV感染率为25.2%(502/1 999),其中16型的感染率为21.2%(69/326)最为常见,其次为52型19.3%(63/326)和58型16.0%(52/326)。与年龄的相关性分析结果显示不同年龄阶段HPV感染率不同,其中41~50岁患者感染率最高,>60岁患者感染率最低。结论:北京地区妇产科门诊患者HPV感染具有明显的亚型分布异质性,提示HPV预防性疫苗的使用应同时考虑分型和年龄的因素。
Objective: To study the status of human papillomavirus (HPV) infection in obstetrics and gynecology clinic in Beijing and their correlation with age, and to provide epidemiological data for the clinical application of HPV vaccine. Methods: A total of 1 999 cases of cervical cell samples from the obstetrics and gynecology clinic of Xuanwu Hospital of Capital Medical University from April 2013 to May 2014 were collected. HPV-DNA genotyping , Age-specific HPV infection rate of different age stratification analysis, combined with age information for statistical analysis. Results: The HPV infection rate was 25.2% (502/1 999) in 1 999 cases of whom the infection rate of type 16 was 21.2% (69/326), followed by that of type 52 (19.3%, 63/326) And 58% of 16.0% (52/326). The results of age-related analysis showed that the HPV infection rates were different in different age groups, of which 41 to 50 years old patients had the highest infection rate, and those aged> 60 years had the lowest infection rate. Conclusion: HPV infection in obstetrics and gynecology outpatient clinics in Beijing has obvious subtype distribution heterogeneity, suggesting that the use of HPV vaccine should be considered both in typing and age.