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目的分析孕早期25羟维生素D及C反应蛋白(CRP)水平与妊娠期糖尿病的相关性。方法对108例产前检查孕妇于孕早期检测25羟维生素D及CRP水平,于孕中期行口服葡萄糖耐量试验(OGTT),比较不同25羟维生素D及CRP水平患者OGTT阳性率,并分析25羟维生素D及CRP的诊断价值。结果 108例孕妇中25羟维生素D水平>30 nmol/L 35例,OGTT阳性5例(14.29%);≤30 nmol/L 73例,OGTT阳性27例(36.99%),2组比较差异有统计学意义(χ2=4.808,P<0.05)。108例孕妇中CRP水平≤8 mg/L 68例,OGTT阳性13例(19.12%);CRP水平>8 mg/L 40例,OGTT阳性19例(47.50%),2组比较差异有统计学意义(χ2=8.417,P<0.05)。25羟维生素D与CRP水平联合检测的特异度和敏感度均高于单独检测,差异有统计学意义(P<0.05)。结论孕早期25羟维生素D低水平及CRP高水平能有效预测妊娠期糖尿病的发生,具有一定的临床诊断价值。
Objective To analyze the correlation between the levels of 25-hydroxyvitamin D and C-reactive protein (CRP) in early pregnancy and gestational diabetes mellitus. Methods A total of 108 prenatal pregnant women were tested for the levels of 25-hydroxyvitamin D and CRP during the first trimester of pregnancy. OGTT was performed in the second trimester. The positive rates of OGTT in 25 patients with different levels of vitamin D and CRP were compared. Diagnostic Value of Vitamin D and CRP. Results Of 108 pregnant women, 25 cases had 25 hydroxyvitamin D levels> 30 nmol / L in 35 cases, OGTT positive in 5 cases (14.29%), ≤30 nmol / L in 73 cases and OGTT positive in 27 cases (36.99%). There were statistically significant differences between the two groups Significance (χ2 = 4.808, P <0.05). 108 cases of pregnant women CRP level ≤ 8 mg / L in 68 cases, OGTT positive in 13 cases (19.12%); CRP level> 8 mg / L in 40 cases, OGTT positive in 19 cases (47.50%), the difference between the two groups was statistically significant (χ2 = 8.417, P <0.05). The specificity and sensitivity of combined detection of vitamin D and CRP levels were higher than those of single test, the difference was statistically significant (P <0.05). Conclusion The low level of 25-hydroxyvitamin D in early pregnancy and the high level of CRP can effectively predict the occurrence of gestational diabetes mellitus, which has some clinical diagnostic value.