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目的了解甲亢患儿骨代谢及氧化应激状态的变化情况。方法选取2013年10月-2016年3月期间宁波市妇女儿童医院诊断与治疗的75例甲亢患儿为观察组,同时选取同时间段期间的75名同龄健康儿童为对照组,分析比较两组儿童的血清骨代谢及氧化应激状态指标表达水平,并将观察组中不同基础代谢率及分型甲亢患儿的血清骨代谢及氧化应激状态指标表达水平进行比较。结果观察组的血清骨代谢指标BGP、ALP、PICP及ICTP分别为(13.28±1.51)μg/L、(142.68±13.96)U/L、(105.87±11.32)μg/L及(10.12±1.53)μg/L,均高于对照组的(7.57±0.82)μg/L、(101.54±9.76)U/L、(3.13±0.25)μg/L及(2.96±0.33)μg/L,血清氧化应激状态指标SOD、CAT、GSH-Px、Vit C、Vit E及MT分别为(65.24±5.20)n U/ml、(40.10±3.84)n U/ml、(73.63±7.07)U/L、(36.46±4.80)μg/ml、(7.10±0.89)μg/ml及(16.12±2.10)ng/L,均低于对照组的(82.52±6.43)n U/ml、(45.36±4.67)n U/ml、(84.98±8.15)U/L、(45.58±5.31)μg/ml、(10.26±1.57)μg/ml及(27.91±3.25)ng/L。观察组中不同基础代谢率甲亢患儿的血清骨代谢及氧化应激状态指标表达水平差异亦有统计学意义(均P<0.05),但不同分型儿童的血清骨代谢及氧化应激状态指标表达水平差异无统计学意义(均P>0.05)。结论甲亢患儿骨代谢及氧化应激状态呈现明显异常的状态,且不同基础代谢率甲亢患儿的表达水平也存在明显差异,因此应重视对此类患儿上述方面的监测与干预。
Objective To investigate the changes of bone metabolism and oxidative stress in children with hyperthyroidism. Methods 75 hyperthyroidism patients diagnosed and treated in Ningbo Women and Children’s Hospital from October 2013 to March 2016 were selected as the observation group and 75 healthy children of same age during the same period were selected as the control group. Children with serum bone metabolism and oxidative stress status indicators, and the observation group with different basal metabolic rate and type Hyperthyroidism serum bone metabolism and oxidative stress status indicators were compared. Results The serum BGP, ALP, PICP and ICTP of the observation group were (13.28 ± 1.51) μg / L, (142.68 ± 13.96) U / L, (105.87 ± 11.32) μg / L and (10.12 ± 1.53) μg / L were significantly higher than those in the control group (7.57 ± 0.82 μg / L, (101.54 ± 9.76) U / L, (3.13 ± 0.25) μg / L and (2.96 ± 0.33) μg / The indexes of SOD, CAT, GSH-Px, Vit C, Vit E and MT were (65.24 ± 5.20) nU / ml, (40.10 ± 3.84) nU / ml and (73.63 ± 7.07) U / 4.80 μg / ml, 7.10 ± 0.89 μg / ml and 16.12 ± 2.10 ng / L, respectively, which were all lower than those in the control group (82.52 ± 6.43) n U / ml and (45.36 ± 4.67) (84.98 ± 8.15) U / L, (45.58 ± 5.31) μg / ml, (10.26 ± 1.57) μg / ml and (27.91 ± 3.25) ng / L respectively. In the observation group, there were also significant differences in serum bone metabolism and oxidative stress status among hyperthyroidism patients with different basal metabolic rate (all P <0.05), but serum bone metabolism and oxidative stress index There was no significant difference in expression level (all P> 0.05). Conclusion The bone metabolism and oxidative stress status of hyperthyroidism patients showed obvious abnormal state, and the expression levels of hyperthyroidism patients with different basal metabolic rate also had significant differences. Therefore, we should pay attention to the monitoring and intervention of these aspects.