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低氧诱导因子(HIF)-1是一种与肿瘤细胞低氧有关的转录因子,它所介导的靶基因在肿瘤血管生成、能量代谢、细胞增殖等方面起重要作用。HIF-1α过表达与肿瘤细胞侵袭、凋亡及预后密切相关。以HIF-1及其靶基因为靶点的抗肿瘤治疗,将是一条令人注目的新途径。
Hypoxia-inducible factor (HIF) -1 is a transcription factor related to hypoxia of tumor cells. Its target gene plays an important role in tumor angiogenesis, energy metabolism and cell proliferation. HIF-1α overexpression is closely related to tumor cell invasion, apoptosis and prognosis. Anti-cancer therapy targeting HIF-1 and its target genes will be an attractive new avenue.