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目的探讨微刺激周期体外受精-胚胎移植(MC-IVF-ET)中促性腺激素释放激素激动剂(GnRH-a)和注射人绒毛膜促性腺激素(hCG)诱导排卵的作用比较及临床应用价值。方法采用SPSS统计软件包对384例行MC-IVF-ET助孕的患者进行观察,比较注射GnRH-a和h CG触发排卵两组患者的获卵数、MⅡ卵数、正常受精率、6~8细胞胚胎率、优质胚胎率、胚胎种植率、临床妊娠率、卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生率、下周期囊肿发生率进行比较。结果 GnRH-a组OHSS发生率、下周期囊肿发生率显著低于hCG组(P<0.05),但两组获卵数、MⅡ卵数、正常受精率、6~8细胞胚胎数、优质胚胎数、胚胎种植率、临床妊娠率均无显著性差异(P>0.05)。结论微刺激周期应用GnRH-a诱导排卵能降低OHSS发生率和下周期囊肿发生率,其刺激周期的可重复性和安全性优于hCG。
Objective To investigate the role of gonadotropin-releasing hormone agonist (GnRH-a) and human chorionic gonadotropin (hCG) -injecting ovulation induction in micro-stimulation cycle in vitro fertilization-embryo transfer (MC-IVF-ET) . Methods 384 patients with MC-IVF-ET-assisted pregnancy were observed by SPSS software package. The number of oocytes, MⅡ oocytes, normal fertilization rate, 8 cell embryo rate, high-quality embryo rate, embryo implantation rate, clinical pregnancy rate, ovarian hyperstimulation syndrome (OHSS) incidence, the incidence of cysts in the next cycle were compared. Results The incidence of OHSS and cyst in the next cycle in GnRH-a group was significantly lower than that in hCG group (P <0.05). However, the number of oocytes, MⅡ oocytes, normal fertilization rate, the number of 6-8 cell embryos, , Embryo implantation rate and clinical pregnancy rate had no significant difference (P> 0.05). Conclusions The induction of ovulation with GnRH-a in the micro-stimulation period can reduce the incidence of OHSS and the incidence of cysts in the next period, and the repeatability and safety of the stimulation period are better than hCG.