评定片剂内在质量的可靠方法,是在人体服药后进行血药浓度或尿药浓度的测定,从而确定其生物利用度。但在日常生产中,要用这种方法来控制药品质量是不可能的,必须寻求一个体外方法来代替体内测定。目前,国内外在进行体外测定时,一般都采用物理测定方法,即溶解速度试验。对于口服固体制剂,在人体内的吸收过程是崩鲜→溶解而转为溶液→被上皮细胞膜吸收而进入血液循环,分布至全身各组织器官。在这一过 A reliable method of assessing the intrinsic quality of a tablet is to determine its bioavailability by measuring the plasma concentration or urinary drug concentration after taking the medicine in humans. However, in daily production, it is impossible to control the quality of medicines by this method. An in vitro method must be sought to replace the in vivo tests. At present, in vitro determination at home and abroad, the general use of physical determination, that is, dissolution rate test. For oral solid preparations, the absorption process in the human body is the collapse of the fresh → dissolved into solution → absorbed by the epithelial cell membrane into the blood circulation, distributed to the body tissues and organs. In this one too