论文部分内容阅读
普通非纯化肝素是由不同长度的粘多糖链组成的混合物,其分子量为5000～30000道尔顿。作为抗凝剂,肝素只能在血浆抗凝血酶Ⅲ的存在下并与其形成复合物才能发挥作用。静注普通肝素平均剂量为400U/kg·24h。对有中度凝血倾向的病人,每隔8～12h 皮下注射5000U 浓的非纯化肝素,可安全有效地防止术后静脉血栓和肺栓塞。如每天3次皮下合并注射5000U 肝素和0.5mg 双氢麦角胺,或调节3次皮下注射肝素的剂量,使激活部分凝血致活酶时间保持在50～70s 之间,则足以预防高凝血倾向病人形成血栓。
Ordinary non-purified heparin is a mixture of mucopolysaccharide chains of different lengths with a molecular weight of 5,000 to 30,000 daltons. As an anticoagulant, heparin works only in the presence of, and in complex with, plasma antithrombin III. Intravenous unfractionated heparin average dose of 400U / kg · 24h. In patients with moderate tendency to coagulation, every 8 ~ 12h subcutaneous injection of 5000U concentrated non-purified heparin, can be safe and effective to prevent postoperative venous thrombosis and pulmonary embolism. Such as 3 times a day subcutaneous injection of 5000U heparin and 0.5mg dihydroergotamine or subcutaneous injection of heparin thrice adjust the dose to activate the partial thromboplastin time between 50 ~ 70s, is sufficient to prevent the tendency of patients with high blood clotting Thrombosis.