50例原发性肝细胞癌标本来自本校附属一院手术切除标本。每一例均作常规石蜡切片和常规超薄切片。在光镜下,肝癌细胞核仁明显增大。数量增多,分化越差的肝癌核仁改变越明显。在电镜下,肝癌细胞核仁改变尤为明显,除了核仁明显增大外,核仁的形态改变也很明显,多为圆形、卵圆 50 cases of primary hepatocellular carcinoma specimens were obtained from the surgical excision specimens of the First Affiliated Hospital. Each case was subjected to routine paraffin sections and conventional ultrathin sections. Under light microscope, the nucleoli of liver cancer cells increased significantly. As the number increases, the worse the differentiation, the more obvious the nucleoli changes. Under the electron microscope, the nucleoli change of liver cancer cells is particularly obvious. In addition to the significant increase in nucleoli, the morphological changes of nucleoli are also obvious, mostly round, oval