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目的：探讨甲泼尼龙冲击疗法（ＭＰＰＴ）对血压和心电图的影响。方法：甲泼尼龙２０ｍｇ／（ｋｇ·ｄ）溶于５％葡萄糖溶液５００ｍＬ中静脉滴注，ｑｄ×（３～５ｄ），对６０例神经免疫性疾病病人实施ＭＰＰＴ，记录输注前后及输注过程的血压和心电图变化。结果：在甲泼尼龙输注过程中，收缩压升高３．５±１．０ｋＰａ（０．５～１０ｋＰａ），舒张压升高１．１±０．６ｋＰａ（０．３～６ｋＰａ），心率增快１６±４次／ｍｉｎ（６～２８次／ｍｉｎ），心电图出现Ｓ－Ｔ和Ｔ波改变１９例，心律失常２３例。在输注结束后３～６ｈ内，血压、心率和心电图改变大务恢复至输注前水平。结论：ＭＰＰＴ可致一过性血压升高和心电图异常。
Objective: To investigate the effect of methylprednisolone therapy (MPPT) on blood pressure and electrocardiogram. Methods: 60 mg / (kg · d) of methylprednisolone was dissolved in 500 mL of 5% dextrose solution for intravenous infusion for qd × (3 ~ 5 d). 60 patients with neuroimmune diseases were treated with MPPT. Process blood pressure and ECG changes. Results: In the course of methylprednisolone infusion, systolic blood pressure increased 3.5 ± 1.0kPa (0.5 ~ 10kPa), diastolic blood pressure increased by 1.1 ± 0.6kPa (0.3 ~ 6kPa), heart rate Increased 16 ± 4 times / min (6 ~ 28 times / min), electrocardiogram appeared S-T and T wave changes in 19 cases, 23 cases of arrhythmia. Within 3 ~ 6h after the end of infusion, blood pressure, heart rate and electrocardiogram changes greatly restored to the level before infusion. Conclusion: MPPT can cause transient hypotension and abnormal ECG.