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目的观察替勃龙联合纳米银凝胶治疗老年萎缩性阴道炎的疗效。方法选择老年性萎缩性阴道炎患者136例分为两组,即治疗组为替勃龙联合纳米银凝胶,对照组为替勃龙联合甲硝唑栓,比较两组临床疗效、临床的情况改善、阴道炎症评分和阴道健康状况评分、局部应用不良反应、1年内复发率。结果两组患者临床疗效、治愈率和有效率相仿,无统计学意义(P>0.05)。治疗后两组患者阴道干燥、性交痛、瘙痒等均消失,而阴道及外阴触痛和阴道及外阴烧灼感治疗组明显优于对照组(P<0.05)。两组局部应用不良反应有显著性差异,即有统计学意义(P<0.05)。1年内治疗组复发率低于对照组。结论应用替勃龙联合纳米银凝胶治疗老年萎缩性阴道炎降低了复发率、减轻阴道局部黏膜刺激作用、减少细菌耐药性、疗效显著、安全、经济、方便,值得临床推广应用。
Objective To observe the curative effect of tibolone combined with nano-silver gel in the treatment of elderly atrophic vaginitis. Methods One hundred and sixty-six patients with senile atrophic vaginitis were divided into two groups: the treatment group was tibolone combined with nano silver gel, the control group was tibolone combined with metronidazole suppository. The clinical curative effect and clinical situation of the two groups were compared Improvement, Vaginal Inflammation Score and Vaginal Health Score, Topical Adverse Reactions, Recurrence Rate Within 1 Year. Results The clinical curative effect, cure rate and effective rate of two groups of patients were similar and had no statistical significance (P> 0.05). The vaginal and vulvar tenderness, vaginal and vulvar burning sensation in the treatment group were significantly better than those in the control group (P <0.05). Adverse reactions between the two groups were significantly different, that is statistically significant (P <0.05). The recurrence rate of the treatment group within one year was lower than that of the control group. Conclusions The application of tibolone combined with nanosilver gel in the treatment of elderly atrophic vaginitis can reduce the recurrence rate, relieve the vaginal mucosal stimulation and reduce the drug resistance of bacteria. The curative effect is significant, which is safe, economical and convenient and worthy of clinical application.