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目的：观察男性狼疮肾炎（ＬＮ）临床、病理表现、免疫学异常及治疗和愈后的情况，并与女性患者比较，以提高对男性ＬＮ的认识。方法：回顾分析１３例男性ＬＮ临床、病理及免疫学资料并与女性ＬＮ作比较。结果：男性在浆膜炎、皮疹和血尿发生率及蛋白尿程度明显高于女性，病理ＩＶ型多见，血管炎及间质损害较明显，女性在抗核抗体（ＡＮＡ）滴度及γ－球蛋白水平较男性明显为高，男性对强的松（Ｐｒｅｄ）、环磷酰胺（ＣＴＸ）治疗效果较女性差，随访ｌ～８年，两组病死率无明显差异。结论：男性ＬＮ在临床表现、肾脏病理、免疫学特征、治疗有别于女性患者。
Objective: To observe the clinical, pathological, immunological abnormalities and treatment and prognosis of male lupus nephritis (LN) and to compare with female patients to improve the understanding of male LN. Methods: The clinical, pathological and immunological data of 13 male LNs were retrospectively analyzed and compared with female LNs. Results: The prevalence of serositis, rash, hematuria and proteinuria were significantly higher in males than in females. The pathological type IV was more common and the vasculitis and interstitial lesions were more obvious. The levels of antinuclear antibody (ANA) titers and γ- Globulin levels were significantly higher in men than in men, and prednisone (Pred) and cyclophosphamide (CTX) were less effective in men than in men. There was no significant difference in mortality between the two groups at follow-up of 1-8 years. Conclusion: The clinical manifestations, renal pathology, immunological characteristics and treatment of male LN are different from those of female patients.