胆管细胞癌(CCA)是一类高度异质性的恶性肿瘤,且早期诊断困难,治疗手段及效果有限.因此,更好地明确CCA的分子病理特点对于其诊断、治疗和预后的改善具有重要意义.随着分子生物学技术的发展,CCA分子病理学机制的研究将逐步深入,有望为临床早期诊断和特异性靶向治疗提供新的思路和途径.笔者对CCA分子病理学的最新研究进展进行综述.“,”Cholangiocarcinoma (CCA) is a very heterogeneous group of neoplasms,for which the early diagnosis is difficult,present treatment methods are inadequate and the treatment effects are also limited.Thus,a detailed knowledge of the molecular pathological profiles of CCA is important for improving its diagnosis,treatment and outcomes.With the development of molecular biological technologies,the molecular pathological mechanisms of CCA will gradually be revealed and clarified,which may provide new ideas and approaches for early diagnosis and targeted therapy of CCA.Here,the authors present the current research progress in molecular pathology of CCA,