目的探讨经皮椎体成形术(PVP)治疗多节段脊柱转移性肿瘤的临床疗效。方法采用PVP治疗22例多节段脊柱转移性肿瘤患者,并于术后3d、6个月、12个月时对患者疼痛缓解程度、生活质量、病椎椎体形态学变化和肿瘤的进一步浸润状况进行评估。结果 22例60节椎体穿刺全部成功,其中10例29节出现骨水泥外渗,未出现肺栓塞、肋骨骨折等其他并发症。术后各时间点VAS及EORTC评分较术前均降低(P<0.01),椎体前缘、中央、后缘高度及Cobb角与术前比较差异有统计学意义(P<0.05)。2例患者的3节病椎有椎弓根肿瘤浸润,2例患者有新发其他椎体转移,其余椎体和附件未见肿瘤进一步浸润。结论 PVP治疗多节段脊柱转移性肿瘤具有良好的止痛效果,能够有效改善患者的生活质量,维持患椎高度及Cobb角,预防椎体进一步塌陷,并可与放疗、化疗等治疗措施联合应用。 Objective To investigate the clinical efficacy of percutaneous vertebroplasty (PVP) in the treatment of multi-segmental spinal metastases. Methods Twenty-two patients with multi-segment spinal metastases were treated with PVP and their pain relief, quality of life, morphological changes of vertebral body and further infiltration of tumor were observed at 3d, 6th and 12th months after operation. Status assessment. Results Twenty-two cases of 60-segment vertebral body puncture were successful. Among them, 10 cases of 29 cases had extravasation of cement and no other complications such as pulmonary embolism and rib fractures occurred. The VAS and EORTC scores at each time point were significantly lower than those before operation (P <0.01). There was significant difference in the anterior, central, posterior edge height and Cobb angle between preoperative and postoperative (P <0.05). Three of the two patients had pedicle tumor infiltration in the diseased vertebrae, two had new vertebral metastases, and the remaining vertebral bodies and attachments showed no further tumor invasion. Conclusion PVP has a good analgesic effect in treating multi-segment spinal metastases, which can effectively improve the quality of life of patients, maintain the height of the affected vertebra and Cobb angle, and prevent further collapse of the vertebral body. It can also be used in combination with radiotherapy and chemotherapy.