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中国仓鼠V_(79)细胞hprt位点由主要引起点突变的甲基磺酸乙酯(EMS)和强MMC断裂剂处理EMS诱发出的剂量依赖性的突变,而MMC的诱变反应微弱。用Southern和Northern印迹法分析突变。
The hprt site of Chinese hamster V_(79) cells was dose-dependently elicited by EMS induced by point mutations of ethyl methanesulfonate (EMS) and strong MMC fragmentation agents, whereas the mutagenic response of MMC was weak. Mutations were analyzed using Southern and Northern blots.