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根据腺管形成、细胞分化及核分裂相将乳腺癌分为三级；浆细胞反应以每个毛细淋巴管周围浆细胞数在５个以上为阳性，基底膜破环与弹力纤维反应也分为三级。观察１４５例乳腺癌，结果发现：乳腺癌Ⅰ级５９例，其中浆细胞反应阳性３８例，占６４．４％；乳腺癌Ⅱ级６７例，浆细胞反应阳性３０例，占４４．８％；乳腺癌Ⅲ级１９例，浆细胞反应阳性４例，占２１．１％。说明浆细胞反应阳性与乳腺癌分级数呈负相关。而各级乳腺癌中，浆细胞反应阴性病例的淋巴结转移分别为６６．７％，６８．４％，７８．５％，说明浆细胞反应程度直影响乳腺癌的淋巴结转移。纤维反应（＋）者１３例，淋巴结阳性３例，占２３．１％，纤维反应（＋＋）者５２例，淋巴结阳性２８例，占５３．８％；纤维反应（＋＋＋）者５９例，淋巴结阳性３５例，占６９．５％。淋巴结转移率与纤维反应分级数呈正相关，从而提示：乳腺癌基底膜破环，弹力纤维增生、变性、固缩均可作为乳腺癌的预后指标。
According to duct formation, cell differentiation and mitotic phase, breast cancer is divided into three grades; plasma cell response is positive for more than 5 plasma cells per lymphatic capillary, and basement membrane destruction and elastic fiber response are also divided into three. level. Observed 145 cases of breast cancer, the results found: 59 cases of grade I breast cancer, including plasma cell reaction in 38 cases, accounting for 64.4%; breast cancer in grade II in 67 cases, plasma cell reaction in 30 cases, accounting for 44.8%; There were 19 cases of grade III breast cancer and 4 cases of positive plasma cell reaction, accounting for 21.1%. The positive plasma cell reaction was negatively correlated with the number of breast cancer grades. At all levels of breast cancer, lymph node metastasis was negative in 66.7%, 68.4%, and 78.5%, respectively, indicating that the degree of plasma cell response directly affected the lymph node metastasis of breast cancer. There were 13 patients with fibrosis (+), 3 with positive lymph nodes (23.1%), 52 with fibrosis (++), 28 with lymph nodes (53.8%), 59 with fibrosis (+++). Positive in 35 cases, accounting for 69.5%. The rate of lymph node metastasis was positively correlated with the number of grades of fiber reaction, suggesting that the basement membrane of breast cancer is destroyed and hyperplasia, degeneration, and contraction of elastic fibers can be used as prognostic indicators of breast cancer.