目的：探讨血浆内皮素（ＥＴ）和一氧化氮（ＮＯ）含量变化在偏头痛发病中的临床意义。方法：采用经颅彩色多普勒超声（ＴＣＤ）检测具有典型脑动脉痉挛频谱表现的５０ 例偏头痛患者，测定其大脑部分动脉的收缩期血流速度（Ｖｓ）、舒张末期血流速度（Ｖｄ）和平均血流速度（Ｖｍ ），大脑中动脉收缩峰血流速度（Ｖｓ ＭＣＡ）／颈内动脉颅外段收缩峰血流速度（Ｖｓ ＩＣＡ）以及血浆ＥＴ和ＮＯ含量，并与４０ 例健康体检者（正常对照组）作比较。结果：偏头痛组Ｖｓ〔（１３４７８±１０６８）ｃｍ ／ｓ〕、Ｖｄ〔（６３３９±５８８）ｃｍ ／ｓ〕、Ｖｍ 〔（９１３０±５５４）ｃｍ ／ｓ〕、Ｖｓ ＭＣＡ／Ｖｓ ＩＣＡ（２３２±０４４）和血浆ＥＴ〔（８２００±２５４５）ｎｇ／Ｌ〕均明显高于正常对照组〔（９１２２±１０２３）ｃｍ ／ｓ、（４６０３±６４３）ｃｍ ／ｓ、（６００３±９２９）ｃｍ ／ｓ、（１７０±０１２）和（６５７１±１１２３）ｎｇ／Ｌ，Ｐ均＜ ００１〕，血浆ＮＯ 含量〔（５６２５±２２２１）μｍ ｏｌ／Ｌ〕明显低于正常对照组〔（７４５２±２０１３）μｍ ｏｌ／Ｌ，Ｐ＜ ００１〕；且随着血管痉挛支数的增加， Objective: To investigate the clinical significance of the changes of plasma endothelin (ET) and nitric oxide (NO) levels in the pathogenesis of migraine. Methods: Totally 50 migraineurs with typical cerebral arterial spasm were examined by transcranial color Doppler ultrasonography (TCD). The systolic blood flow velocity (Vs), end diastolic blood flow velocity (Vd ) And mean arterial blood flow velocity (Vm), Vs MCA / Vs ICA and plasma ET and NO in 40 patients Physical examination (normal control group) for comparison. Results: Vs 〔(13478 ± 1068) cm / s〕, VD 〔(6339 ± 588) cm / s〕, Vm 〔(9130 ± 554) cm / s], Vs MCA / Vs ICA (232 ± 044) and plasma ET 〔(8200 ± 2545) ng / L〕 were significantly higher than those in the normal control group 〔(9122 ± 1023 (4603 ± 643) cm / s, (6003 ± 929) cm / s, (1.70 ± 0.12) and (6571 ± 1123) ng / L, P <0.01), and plasma NO content (56.25 ± 22.21) μmol / L was significantly lower than that of the normal control group (74.52 ± 20.13) μmol / L , P <001〕; and with the increase of vascular spasm count,