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以6-O-乙烯基己二酸-D-吡喃型半乳糖(OVNGA)和温敏性的二聚乙二醇单甲醚甲基丙烯酸甲酯(DEGMA)作为单体,采用酶促法、可逆加成-断裂链转移自由聚合法(RAFT)和“一锅法”联用,并与金纳米粒子(AuNPs)复合,制备了具有温敏性的含半乳糖基的PDEGMA-b-POVNGA@AuNPs复合物。通过1HNMR、FTIR和GPC对PDEGMA-b-POVNGA进行了结构表征,UV-Vis、TEM和DLS对AuNPs和PDEGMA-b-POVNGA@AuNPs进行了性能测试,变温UV-Vis对PDEGMA-b-POVNGA及PDEGMA-b-POVNGA@AuNPs复合物进行了温敏性考察。结果表明:PDEGMA-b-POVNGA@AuNPs复合物是由PDEGMA-b-POVNGA和AuNPs以S—Au键键合,将聚合物接枝到了AuNPs表面。PDEGMA-b-POVNGA的Mn和Mw分别为9.42×104和1.45×105。AuNPs平均粒径为25 nm。PDEGMA-b-POVNGA和PDEGMA-b-POVNGA@AuNPs的低临界温度(LCST)分别约为35.0和34.5℃。
Using 6-O-vinyl-adipic acid-D-galactopyranose (OVNGA) and temperature-sensitive diethylene glycol monomethyl ether methyl methacrylate (DEGMA) as monomers, , Reversible addition-fragmentation chain transfer free-radical polymerization (RAFT) and “one-pot method” were used in combination with gold nanoparticle (AuNPs) to prepare a thermosensitive galactosyl-containing PDEGMA-b -POVNGA @ AuNPs complex. The structure of PDEGMA-b-POVNGA was characterized by 1HNMR, FTIR and GPC. The properties of AuNPs and PDEGMA-b-POVNGA @ AuNPs were tested by UV-Vis, TEM and DLS. PDEGMA-b-POVNGA @ AuNPs complexes were investigated. The results showed that PDEGMA-b-POVNGA @ AuNPs complex was grafted onto the surface of AuNPs by S-Au bonding of PDEGMA-b-POVNGA and AuNPs. The Mn and Mw of PDEGMA-b-POVNGA were 9.42 × 104 and 1.45 × 105, respectively. AuNPs average particle size of 25 nm. The low critical temperature (LCST) of PDEGMA-b-POVNGA and PDEGMA-b-POVNGA @ AuNPs were about 35.0 and 34.5 ° C, respectively.