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大骨节病国际上称Kaschin-Beck Disease(KBD)是一种地方性、多发性、变形性骨关节病。多发生于儿童,以关节软骨、骺软骨和骺软骨板变性坏死为基本病变的地方性骨病[1]。严重病例可致矮小畸形、终生残废。在我国主要分布在东北至西藏的一个狭长高寒地带,在国外,本病见于苏联的西伯利亚和朝鲜北部山区。病因至今不完全清楚。大骨节病主要影响着儿童及青少年的健康成长,对此,我国从新中国成立后,主要创新性工作表现在流行病学研究[2],目前尽管生活水平提高,大骨节病的发生率大幅度下降,但是在一些偏远地带大骨节病还有发生,影响着我国国民经济的增长。
Kaschin-Beck Disease (KBD) is an endemic, multiple, degenerative osteoarthritis. Occurred in children, with articular cartilage, epiphyseal cartilage and epiphyseal cartilage degeneration and necrosis of the basic lesions of endemic bone disease [1]. Serious cases can cause short deformities, life-long disability. In our country is mainly distributed in a narrow and alpine zone from northeast to Tibet, outside the country, the disease seen in the Soviet Union of Siberia and northern mountains of North Korea. Etiology is not entirely clear so far. Kashin-Beck disease mainly affects the healthy growth of children and adolescents. In this regard, after the establishment of the People’s Republic of China in 1949, major innovative work has been carried out in epidemiological studies [2]. At present, despite the improvement of living standards, the incidence of Kashin-Beck disease Decline, but in some remote areas Kashin-Beck disease still occurred, affecting the growth of our national economy.