目的对参与调节大肠肿瘤细胞凋亡的三种基因蛋白（ｐ５３，ｃ┐ｍｙｃ，ｂｃｌ┐２）表达情况进行研究。方法应用免疫组化方法对４２例良性大肠肿瘤和５４例大肠癌进行检测。结果良性肿瘤三种基因产物ｐ５３，ｃ┐ｍｙｃ，ｂｃｌ┐２的阳性率分别为：４．８％、５２．３％和６６．７％。大肠癌则分别为：５１．９％、７５．９％和８５．２％。结论在大肠肿瘤形成过程中，ｂｃｌ┐２、ｃ┐ｍｙｃ基因产物表达变化较ｐ５３蛋白过渡表达为早。对大肠肿瘤早期进行上述三种基因产物的监测具有重要意义。 Objective To study the expression of three gene proteins (p53, c┐myc, bcl┐2) involved in the regulation of apoptosis of colorectal tumors. Methods 42 cases of benign colorectal tumors and 54 cases of colorectal cancer were detected by immunohistochemistry. Results The positive rates of three gene products p53, c┐myc, bcl┐2 in benign tumors were: 4.8%, 52.3% and 66.7%, respectively. Colorectal cancers were: 51.9%, 75.9%, and 85.2%. Conclusion During the process of colorectal neoplasms, the expression of bcl┐2 and c┐myc gene products is earlier than that of p53 protein. It is of great significance to monitor the above three gene products in the early stage of colorectal tumors.