论文部分内容阅读
目的探讨病毒性脑炎急性期继发性全身性强直-阵挛发作的危险因素。方法资料完整的急性病毒性脑炎患者374例,其中,病例组继发性全身性强直-阵挛发作组72例,对照组(无抽搐发作组)259例,系同期住院患者;病例组和对照组采用统一的调查表,用MicrosoftAccess2002建立数据库,共52个主项内容,部分主项有下属分项;对研究资料先进行单因素分析,然后进行多因素非条件Logistic回归模型分析。结果经分析筛选出大脑皮质损害、多灶性损害、脑电图异常、昏迷、颅内压升高等5个因素为脑炎后继发癫痫间的独立危险因素。结论病毒性脑炎后急性期强直-阵挛发作的发生主要与大脑皮质损害关系密切,昏迷、颅内压升高可促发脑炎后强直-阵挛发作。
Objective To investigate the risk factors of secondary systemic tonic-clonic seizures in the acute phase of viral encephalitis. Methods A total of 374 patients with acute viral encephalitis were enrolled. Among them, there were 72 cases of secondary generalized tonic-clonic seizure and 259 cases of control group (without seizure) in the same period of inpatients; cases and Control group using a unified questionnaire, using MicrosoftAccess2002 to establish a database, a total of 52 main content, some of the main subordinate sub-items; research data first univariate analysis, and then multivariate non-conditional Logistic regression model analysis. Results Five factors were identified as cerebral cortex damage, multifocal damage, abnormal EEG, coma, and increased intracranial pressure. Conclusions The incidence of tonic-clonic seizures in the acute post-viral encephalitis is mainly related to cerebral cortex damage. Coma and increased intracranial pressure may trigger tonic-clonic seizure after encephalitis.