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[目的]评价重组人脑利钠肽(rh‐BNP)对顽固性心衰治疗的近期疗效.[方法]顽固性心衰患者60例,随机分为对照组和观察组,各30例,对照组采用常规抗心衰治疗,观察组在此基础上加用 rh‐BNP 治疗,分别观察两组治疗前、治疗后1 d 、3 d 、7 d 症状并同时检测血清 pro‐BNP ,并记录治疗前和治疗后7 d 左室射血分数( LVEF)、左室舒张末期容积(LVEDV )、左室收缩末期容积(LVESV ).[方法]观察组治疗后心衰症状明显改善( P <0.05),且明显优于对照组( P <0.05);观察组治疗后1 d 、3 d 、7 d 血清 pro‐BNP 逐渐下降( P <0.05),且均明显低于同期对照组( P <0.05);观察组治疗后超声心动图相关指标改善优于同期对照组( P <0.05).[结论]rh‐BNP 治疗顽固性心衰近期效果明显.“,”Objective] To evaluate the short‐term efficacy of recombinant human brain natriuretic peptide (RhBNP) for the treatment of intractable heart failure .[Methods]A total of 60 patients with intractable heart failure were randomly divided into control group (n = 30) and observation group(n = 30) .Control group re‐ceived the routine therapy ,while observation group additionally received rhBNP based on routine therapy .The symptoms were observed before and 1 ,3 and 7d after treatment .Meanwhile ,serum pro‐BNP was detected . Left ventricular ejection fraction (LVEF) ,left ventricular end‐diastolic volume (LVEDV ) and left ventricular end‐systolic volume(LVESV) before and 7d after therapy were recorded .[Results]Symptoms of observation group were improved obviously ( P < 0 .05) ,and obviously better than those in control group( P < 0 .05) .Se‐rum pro‐BNP in observation group 1 ,3 and 7d after therapy decreased gradually ( P < 0 .05) ,and was signifi‐cantly lower than that in control group in the corresponding time period ( P < 0 .05) .The improvement of the indexes of ultrasoundcardiogram in observation group was better than that in control group in the correspond ‐ing time period( P < 0 .05) .[Conclusion] The short‐term efficacy of rhBNP for the treatment of intractable heart failure is obvious .