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目的探究单核苷酸多态性rs1885068不同基因型与脑卒中及其亚型患病风险的相关性。方法采用多中心病例-对照研究设计,共纳入全国7个中心1526例脑卒中患者、1561例正常对照。采用聚合酶链式反应-连接酶检测反应(PCR-LDR)技术检测病例组和对照组单核苷酸多态性rs1885068基因型。结果未发现单核苷酸多态性rs1885068基因型与脑卒中及其各亚型患病风险的显著相关性,但单核苷酸多态性rs1885068与腔隙性脑梗死(OR=1.22;95%CI:0.98-1.52;P=0.076;显性模型)和脑出血(OR=1.39;95%CI:1.00-1.93;P=0.052;隐性模型)患病风险的分析中得到边缘阳性的结果 ,T等位基因可能增加腔隙性脑梗死和脑出血的患病风险。结论单核苷酸多态性rs1885068可能与腔隙性脑梗死和脑出血的患病风险相关。
Objective To investigate the association between different genotypes of SNP rs1885068 and the risk of stroke and its subtypes. Methods A multicenter case-control study was designed. A total of 1526 stroke patients and 1561 normal controls were included in 7 centers in China. Polymerase chain reaction-ligase detection reaction (PCR-LDR) was used to detect SNP rs1885068 genotypes in case group and control group. Results There was no significant association between SNP rs1885068 genotype and the risk of stroke and its subtypes. However, single nucleotide polymorphism rs1885068 was associated with lacunar infarction (OR = 1.22; 95 % CI: 0.98-1.52; P = 0.076; dominance model) and cerebral hemorrhage (OR = 1.39; 95% CI: 1.00-1.93; P = 0.052; recessive model) , T allele may increase the risk of lacunar infarction and cerebral hemorrhage. Conclusion Single nucleotide polymorphism rs1885068 may be associated with the risk of lacunar infarction and cerebral hemorrhage.