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目的 :研究奥美拉唑四联疗法治疗Hp阳性十二指肠球部溃疡疗效、安全性 ,比较奥美拉唑四联疗法 ,法莫替丁四联疗法的溃疡愈合率 ,Hp根除率及主要副作用发生率。方法 :6 0例经胃镜证实Hp阳性的十二指肠球部溃疡患者 ,随机分成奥美拉唑组 (A组 )和法莫替丁组 (B组 ) ,A组用药奥美拉唑 2 0mgqd× 2周 ,甲硝唑 0 .2Tid× 1周 ,丽珠得乐 110mgTid× 1周 ,羟氨苄青霉素 0 .5Tid× 1周。B组用药法莫替丁 2 0mgBid× 2周 ,丽珠得乐 110mgTid× 1周 ,甲硝唑 0 .2Tid× 1周 ,羟氨苄青霉素 0 .5Tid× 1周。停药 1月后复查胃镜及复测Hp ,观察溃疡愈合 ,Hp根除及主要副作用。结果 :溃疡愈合率A组、B组分别为 10 0 %、80 % ,Hp根除率为 93.3%、73.3% ,主要付作用发生率为 2 3.3%、2 0 % ,A、B两组之间比较 ,溃疡愈合率 ,Hp根除率结果均有显著差异 (P<0 .0 5 ) ,主要副作用无显著差异 (P >0 .0 5 )。结论 :奥美拉唑四联疗法与法莫替丁四联疗法治疗Hp阳性十二指肠球部溃疡的溃疡愈合率 ,Hp根除率有显著性差异 ,主要付作用无显著差异。
OBJECTIVE: To study the efficacy and safety of omeprazole quadruple therapy in the treatment of Hp-positive duodenal ulcer and to compare the ulcer healing rate, Hp eradication rate and clinical efficacy of omeprazole quadruple therapy and famotidine quadruple therapy The main incidence of side effects. Methods: Sixty patients with Hp-positive duodenal ulcer confirmed by endoscopy were randomly divided into two groups: the omeprazole group (group A) and the famotidine group (group B). The patients in group A received omeprazole 2 0mgqd × 2 weeks, metronidazole 0.2Tid × 1 week, Livzonde 110mgTid × 1 week, amoxicillin 0.5Tid × 1 week. B group drug famotidine 20mgBid × 2 weeks, Livzonol 110mgTid × 1 week, metronidazole 0.2Tid × 1 week, amoxicillin 0.5Tid × 1 week. After discontinuation of gastroscopy in January and retest Hp, observed ulcer healing, Hp eradication and the main side effects. Results: The healing rates of ulcer were 100% and 80% in group A and group B, respectively. The rates of eradication of Hp were 93.3% and 73.3%, respectively. The main incidence of adverse reactions was 23.3% and 20% respectively. Between groups A and B, The results of ulcer healing and Hp eradication showed significant differences (P <0.05), with no significant difference in the main side effects (P> 0.05). Conclusion: The combination of omeprazole quadruple therapy and famotidine quadruple therapy in the treatment of Hp-positive duodenal ulcer ulcer healing rate, Hp eradication rate were significantly different, the main pay no significant difference.