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本文报告的18例由各种不同原因引起的下肢末梢缺血性坏死,在用654-2及低分子右旋糖酐于患侧股动脉注射后,除1例由糖尿病引起的下肢末梢坏死无效外,其余17例均在短期内获得了显著疗效。同时就上述药物的作用机理进行了讨论。认为该药对血管平滑肌的解痉和疏通作用,以及血液稀释,血容量增加,血细胞解聚,血液粘稠度下降等,改善了患肢末梢循环,促使坏死和溃疡病灶的愈合。
This article reports 18 cases of lower extremity ischemic necrosis caused by a variety of reasons, after using 654-2 and low molecular weight dextran in the ipsilateral femoral artery injection, in addition to a case of lower extremity caused by diabetes peripheral necrosis is invalid, the rest 17 cases were in a short period of significant effect. At the same time on the mechanism of action of the drug were discussed. That the drug on the vascular smooth muscle spasm and unblocking effect, and hemodilution, increased blood volume, blood cell depolymerization, decreased blood viscosity, etc., to improve peripheral limb limbs, prompting the healing of necrosis and ulcer lesions.