肺癌晚期约 5 0 %患者并发胸积液 ,且胸腔积液生长迅速 ,一般化疗效果欠佳。我们应用羟基喜树碱加凝血酶胸腔内注入治疗 ,疗效较好 ,现将结果报道如下。1　临床资料1 1　病例选择　癌性胸积液 2 0例 ,男 8例 ,女 12例 ,年龄 35～ 70岁 ,所有患者胸积液病理细胞均为阳性 ,治疗前 About 50% of patients with advanced lung cancer develop pleural effusion, and pleural effusion grows rapidly. The general effect of chemotherapy is poor. We used hydroxycamptothecin plus thrombin intrapleural injection therapy, the effect is good, the results are reported below. 1 Clinical data 1 1 Case selection 20 cases of cancerous pleural effusion, 8 males and 12 females, aged 35 to 70 years old, all patients with pleural effusion pathological cells were positive, before treatment