应用~3H-TdR掺入量测定法观察了氟尿嘧啶对妊娠小鼠及其胚胎细胞的DNA合成抑制作用。按40,80,120mg/kg剂量,将氟尿嘧啶注射于孕鼠腹腔时,脾从40mg/kg,肾和胚胎从80mg/kg开始~3H-TdR掺入量明显减少,与对照组比较均有显著差异,并除脾脏外呈剂量效应关系。 Inhibitory effect of fluorouracil on DNA synthesis of pregnant mice and their embryonic cells was observed using the ~3H-TdR incorporation assay. At doses of 40, 80, 120 mg/kg, when fluorouracil was injected into the peritoneal cavity of pregnant mice, the incorporation of 3H-TdR was significantly reduced from 40 mg/kg in the spleen and from 80 mg/kg in the kidney and embryos, and there was a significant difference from the control group. , and showed a dose-effect relationship with the spleen.