[Objective]Extraction technology of resveratrol from Polygonum cuspidatum was filtrated. [Methods]Using microwave-assisted extraction of resveratrol from Polygonum cuspidatum and resveratrol extraction rate as the index,the index was controlled by the usage of HPLC method. The single factor experiment and orthogonal experimental design method L9( 34) were adopted to select the best extraction technology.[Results]The optimum technology of microwave-assisted extraction of resveratrol from Polygonum cuspidatum was: With microwave power 100W; temperature 25 ℃; microwave time 10 min; material ratio of 1∶20; under that condition,the extraction rate of resveratrol from Polygonum cuspidatum can reach to 0. 914 5%. [Conclusions]The microwave-assisted extraction process is stable and feasible,which is better than the water circumfluence. [Objective] Extraction technology of resveratrol from Polygonum cuspidatum was filtrated. [Methods] Using microwave-assisted extraction of resveratrol from Polygonum cuspidatum and resveratrol extraction rate as the index, the index was controlled by the usage of HPLC method. The single factor experiment and orthogonal experimental design method L9 (34) were adopted to select the best extraction technology. [Results] The optimum technology of microwave-assisted extraction of resveratrol from Polygonum cuspidatum was: with microwave power 100W; temperature 25 ° C; microwave time 10 min; material ratio of 1:20; under that condition, the extraction rate of resveratrol from Polygonum cuspidatum can reach to 0. 914 5%. [Conclusions] The microwave-assisted extraction process is stable and feasible, which is better than the water circumfluence.