论文部分内容阅读
骨髓增生异常综合征(MDS)表现为一种造血干细胞克隆异常性疾病,进而发展为白血病前期(白前)状态,在早期阶段可能有一系列症状,但很难用常规病理学技术检出,该过程以遗传变化为特征,并导致细胞增殖和分化的调控异常.多数情况下,随克隆细胞的演化,染色体畸变也增加,骨髓恶性特征增加,最终发展为急性粒细胞白血病.MDS可能是由于化学性或放射性侵袭骨髓后引起的.FAB小组对MDS进行了分类,确定有5种类型,并认为它们体现白前状态发展的不同阶段.细胞
Myelodysplastic syndrome (MDS) manifests itself as a hematopoietic stem cell abnormality and then develops into a pre-leukemia state. It may have a series of symptoms at an early stage but is difficult to detect by routine pathological techniques. The process is characterized by genetic changes and leads to abnormal regulation of cell proliferation and differentiation.In most cases, along with the evolution of cloned cells, chromosome aberrations also increase, and the malignant characteristics of bone marrow increase and eventually develop into acute myeloid leukemia.MDS may be due to chemical Or radioactive invasion of the bone marrow caused by the FAB group MDS were classified to determine the five types and that they reflect the different stages of pre-white state of development.