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目的调查本地区女性泌尿生殖道支原体感染状况及对常用抗菌药物的耐药性,为临床合理治疗提供依据。方法回顾性分析2011年-2015年于本院妇科就诊的4 942例患者支原体培养、鉴定及药敏试验资料。结果服务业从业者、小学及以下者、19岁~30岁患者支原体感染率最高,差异均有统计学意义(P<0.05)。总感染率为48.9%,连续5年支原体的阳性检出率总体呈上升趋势,主要以解脲脲原体(Uu)单独感染为主,占74.6%,3种感染类型对罗红霉素、阿奇霉素、氧氟沙星和左氧氟沙星的耐药率均>40.0%,对美满霉素、强力霉素和交沙霉素保持良好的抗菌活性,耐药率均<10.0%。结论支原体感染与职业、文化程度、年龄等因素有关,本地区女性泌尿生殖道支原体感染率呈逐年上升趋势,并以Uu单独感染为主,治疗支原体感染应注意流行病学因素和药敏试验结果,美满霉素、强力霉素和交沙霉素可作为首选经验用药。
Objective To investigate the prevalence of mycoplasma infection and its resistance to commonly used antimicrobial agents in women in this area and provide the basis for clinical reasonable treatment. Methods A retrospective analysis of mycoplasma culture, identification and drug susceptibility testing data was conducted in 4 942 patients attending gynecology department in our hospital from 2011 to 2015. Results Service workers, primary school and below, 19 years old to 30 years of patients with mycoplasma infection rate was the highest, the difference was statistically significant (P <0.05). The overall infection rate was 48.9%. The positive detection rate of Mycoplasma for 5 consecutive years showed an overall upward trend, mainly taking UU as the sole infection, accounting for 74.6%. The three infection types were positive for roxithromycin, Azithromycin, ofloxacin and levofloxacin resistant rates were> 40.0%, the minocycline, doxycycline and josamycin maintained good antibacterial activity, resistance rates were <10.0%. Conclusions Mycoplasma infection is related to occupational, educational level and age. The prevalence of mycoplasma in the genitourinary tract of women in this area is increasing year by year. Uu is the main cause of mycoplasma infection. Epidemiological factors and susceptibility testing results should be paid attention to in treating mycoplasma infection , Minocycline, doxycycline and josamycin can be used as the preferred experience medication.