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两组实验各用麻醉狗九只。第一组:阻断两侧颈总动脉,肺动脉压(PAP)平均升高1cmH_2O:呼吸缺氧(吸入9.8％低氧氮气),PAP平均升高3.7cmH_2O;阻断与缺氧同时作用(相当于排除了缺氧对颈动脉体化学感受器的作用),PAP平均升高6.4cmH_2O,大于阻断与缺氧单独作用时PAP升压值之和(4.7cmH_2O),并且有显著差异(P<0.01),说明颈动脉体化学感受器反射的参与能对抗缺氧的缩肺血管作用,限制PAP异常升高。第二组:肺动脉内注射嘧胆碱(Hc-3,15～65μg/kg),阻断肺内乙酰胆碱(Ach)的合成代
Two experimental anesthesia dogs nine each. The first group: On both sides of the common carotid artery, pulmonary artery pressure (PAP) increased by 1cmH2O average: respiratory hypoxia (inhaled 9.8% hypoxic nitrogen), PAP increased by 3.7cmH2O average; blocking and hypoxia simultaneously (P <0.01), the effect of hypoxia on the carotid body chemoreceptor was excluded. PAP increased by 6.4cmH2O on average, which was larger than the sum of PAP increase (4.7cmH2O) in blocking and hypoxia alone ), Indicating that the involvement of carotid body chemoreceptor reflex can counteract the hypoxic pulmonary vasoconstriction and limit the abnormal increase of PAP. The second group: pulmonary artery injection of choline (Hc-3, 15 ~ 65μg / kg), blocking the synthesis of acetylcholine (Ach) in the lung