本综合征首先在美国于1989年10月报道,其后认为该病特点为嗜酸性粒细胞增高及肌肉疼痛,大部分患者均服用必需氨基酸中的色氨酸。此病除上述两大症状外尚可见多种皮肤症状。本文就文献记载予以介绍。美国民间曾用天然食品店和保健食品店中购置的色氨酸治疗失眠症和抑郁症。1989年服用者突然出现上述症状,最终命名为eosinophilia-myalgia综合征。美国疾病控制中心(CDC)到1990年5月底已报告1000多例,1989年CDC诊断标准有下列3项。(1)末梢血中嗜酸性粒细胞≥1000/mm~3 This syndrome was first reported in the United States in October 1989 and was later characterized as eosinophilia and muscle pain, with most patients taking tryptophan in the essential amino acids. The disease in addition to the above two symptoms are still visible a variety of skin symptoms. This article describes the literature. Native Americans used tryptophan purchased from natural and health food stores to treat insomnia and depression. In 1989, the sudden onset of the above symptoms, eventually named eosinophilia-myalgia syndrome. The United States Centers for Disease Control (CDC) by the end of May 1990 has reported more than 1,000 cases, the 1989 CDC diagnostic criteria have the following three. (1) peripheral blood eosinophils ≥ 1000 / mm ~ 3