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目的探讨纤维蛋白胶在乳腺癌根治性术中的应用价值。方法将69例乳腺癌手术的患者随机分成两组,一组34例使用纤维蛋白胶喷洒创面(使用组),另一组35例不用纤维蛋白胶(对照组),然后统计术后72h的引流量,延迟拔管数及皮瓣坏死数及住院时间、患侧上肢功能等。结果使用纤维蛋白胶组术后72h的引流量平均为102ml,明显低于对照组的236ml。使用组延迟拔管3例(5.5%),对照组延迟拔管11例(30.1%),差异具有统计学意义(P<0.01)。使用组皮瓣坏死6例(17.4%),对照组皮缘坏死7例(20.0%),P>0.05。结论乳腺癌改良根治术中使用纤维蛋白胶能减少术后创面渗出,减少皮瓣下积液,缩短术后拔管时间,有利于术后患者早期恢复,但并不能减少术后患者皮瓣坏死率。
Objective To investigate the value of fibrin glue in the radical surgery of breast cancer. Methods Sixty-nine patients undergoing breast cancer surgery were randomly divided into two groups. One group included 34 patients treated with fibrin glue and the other group 35 patients without fibrin glue (control group) Flow, the number of delayed extubation and the number of flap necrosis and hospital stay, ipsilateral upper limb function. Results The average drainage volume at 72h after using fibrin glue group was 102ml, which was significantly lower than 236ml in the control group. Delayed extubation in 3 cases (5.5%) and control group delayed extubation in 11 cases (30.1%), the difference was statistically significant (P <0.01). There were 6 cases (17.4%) with group flap necrosis and 7 cases (20.0%) with skin flap necrosis in control group, P> 0.05. Conclusion Fibrin glue can reduce postoperative wound exudation, reduce effusion under the flap and shorten the time of extubation after the modified radical mastectomy for breast cancer, which is beneficial to the early recovery of postoperative patients, but it can not reduce the postoperative flap Necrosis rate.