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目的探讨大剂量戊酸雌二醇应用对中重度宫腔粘连电切分离术后再次粘连的预防效果。方法 74例中重度宫腔粘连患者随机分为观察组及对照组,各37例。两组均采用宫腔镜分离手术治疗,术后观察组口服戊酸雌二醇,10 mg/d,对照组口服戊酸雌二醇,5 mg/d,连续治疗3个周期。观察治疗后两组月经量、宫腔镜粘连变化情况及临床疗效与不良反应发生情况。结果观察组治疗后平均月经量(52.7±16.2)ml优于对照组的(33.6±8.1)ml,观察组复查宫腔镜可见粘连带者为21.6%,少于对照组的37.8%(P<0.05)。观察组总有效率为94.6%,高于对照组的81.1%(P<0.05)。结论中重度宫腔粘连电切分离术后应用大剂量戊酸雌二醇治疗可有效减少粘连再发,提高临床治疗效果,且不良反应轻微,临床应用安全可靠。
Objective To investigate the preventive effect of high-dose estradiol valerate on the re-adhesions after moderate-to-severe intrauterine adhesions resection. Methods Seventy-four patients with moderate-to-severe uterine adhesions were randomly divided into observation group and control group, 37 cases in each group. Hysteroscopic surgery was used in both groups. Estradiol valerate was orally administered to the observation group after oral administration of estradiol valerate at a dose of 10 mg / day. The control group was given estradiol valerate 5 mg once daily for 3 cycles. After treatment, menstrual flow, hysteroscopic adhesions, clinical efficacy and adverse reactions were observed. Results The average amount of menstrual flow (52.7 ± 16.2) ml in the observation group was significantly better than that in the control group (33.6 ± 8.1) ml, while in the observation group, 21.6% in the hysteroscopy was less than that in the control group (37.8%, P < 0.05). The total effective rate in the observation group was 94.6%, which was higher than that in the control group (81.1%, P <0.05). Conclusions The application of high-dose estradiol valerate after moderate-to-severe intrauterine adhesions resection can effectively reduce the recurrence of adhesions and improve the clinical curative effect with mild adverse reactions. The clinical application is safe and reliable.