肺是血管结缔组织丰富的脏器,是胶原病常侵犯的部位,可以引起肺纤维化、间质性肺炎、局限性肺气肿、血管炎、细支气管炎、肺高压症、肺出血以及胸膜炎。硬皮病(PSS)尤其是病程长者合并间质性肺炎、肺纤维化者多见,多为进行性肺纤维化。胶原病发生肺血管病变可造成突然死亡,SLE 可见肺出血,RA(慢性风湿性关节炎)可合并严重的阻塞性细支气管炎。系统性红斑狼疮(SLE)的病理表现较明确,即由抗DNA 抗体形成的免疫复合物是皮肤、肾、关节等组织损害的主要病因。另由自身抗体(抗红细胞自身抗体)也可引起直接损害。SLE 急性期血液中淋巴细胞减少与抗淋巴细胞抗体有关。也有认为抑制T 淋巴细胞功能减低,引起B 淋巴细胞增殖而致自身免疫增强。RA 被认为是抗变性IgG 抗体产生风湿因子,与这 Pulmonary connective tissue is rich in blood vessels, is a site of collagen disease often infringement, can cause pulmonary fibrosis, interstitial pneumonia, localized emphysema, vasculitis, bronchiolitis, pulmonary hypertension, pulmonary hemorrhage and pleurisy . Scleroderma (PSS), especially the disease course elderly with interstitial pneumonia, pulmonary fibrosis more common, mostly progressive pulmonary fibrosis. Pulmonary vascular lesions of collagen disease can cause sudden death, pulmonary hemorrhage can be seen in SLE, RA (chronic rheumatoid arthritis) can be combined with severe obstructive bronchiolitis. The pathological manifestation of systemic lupus erythematosus (SLE) is more clear, that is, the immune complex formed by anti-DNA antibody is the main cause of tissue damage such as skin, kidney and joint. Another by autoantibodies (anti-red blood cell autoantibodies) can also cause direct damage. SLE acute phase of blood lymphopenia and anti-lymphocyte antibodies. It is also believed that inhibition of T lymphocyte function decreased, causing B lymphocyte proliferation caused by increased autoimmunity. RA is thought to be an anti-idiotic IgG antibody that produces rheumatoid factor, with this